Levels of deoxyribonuclease I (DNase I) activityin vivo have been shown to be altered by physiological and⁄or pathological processes. However, no information is available on the regulation of DNase I gene (DNASE1) expressionin vivo orin vitro. We first mapped the transcription start sites ofDNASE1in human pancreas and in the DNase I-producing human pan-creatic cancer cell line QGP-1, and revealed a novel site 12 kb upstream of exon 1, which was previously believed to be the single transcription-starting exon. .
