Organic agriculture as well as good agricultural practices (GAPs) intrigues the concern of both consumers and producers of agricultural commodities. Bio-preparates of various rhizospheric microorganisms (RMOs) are potential sources of biological inputs supporting plant nutrition and health. The response of open-field potatoes to the application of RMO bio-preparates, the biofertilizer ‘‘Biofertile’’ and the bioagent ‘‘Biocontrol’’, were experimented over 5 successive years under N-hunger of north Sinai desert soils. Both vegetative and tuber yields of a number of tested cultivars were significantly improved due to rhizobacterial treatments. In the majority of cases, the biofertilizer ‘‘Biofertile’’ did successfully supply ca. 50% of plant N requirements, as the yield of full N-fertilized plants was comparable to those received 50% N simultaneously with bio-preparates treatment. The magnitude of inoculation was cultivardependent; cvs. Valor and Oceania were among the most responsive ones. Bio-preparate introduction to the plant–soil system was successful via soaking of tubers and/or spraying the plant canopy. The ‘‘Biocontrol’’ formulation was supportive in controlling plant pathogens and significantly increased the fruit yields. The cumulative effect of both bio-preparates resulted in tuber yield increases of ca. 25% over control. | Bio-preparates support the productivity of potato plants grown under desert farming conditions of north Sinai: Five years of field trials