Domestication is the process in which plants are genetically modified over time by humans for traits that are more advantageous or desirable for humans. A set of morphological, biochemical, and physiological traits that distinguishes domesticated plants from their wild progenitor is known as domestication syndrome. Reduction/loss of means of dispersal reduction/loss of dormancy, compact growth habit, earliness, gigantism, photoperiod insensitivity, reduction/loss of toxic substances is the major elements of domestication syndrome. Studying the crop domestication in detail will help us to uncover the hidden variability in crop wild relatives and can help in further crop improvement and thereby ensure the food security.