Antibiotic resistance and the particular emergence of multi - resistant bacterial strains are clinically relevant issue involving serious threats to public health worldwide. DNA methylation, which changes the affinity and interaction of regulatory proteins with DNA, is an epigenetic mechanism that regulates numerous bacterial physiological processes, including chromosome replication, DNA segregation, mismatch repair, transposition and transcription. DNA adenine methylase (Dam), which methylates N-6 of adenine in the GATC sequence, plays a key role in the gene expression of bacterial virulence. Current antibiotic – resistant studies were gradually associated with adenine methyltransferase (DAM), an inhibitor of DNA, which plays a key role in the pathogenesis of bacteria. DAM is essential in regulating the replication and gene expression of the bacterium. The emergence of DAM in epigenetics studies facilitates the drug discovery of this multiresistant pathogen. The goal of the review is to examine the status and challenges of the antibiotic resistance study in relation to bacterial DNA Adenine Methyltransferase. | Bacterial DNA Adenine Methyltransferase as a novel drug target for antibiotics: Current status and future drug discovery challenges
