The present study was aimed at evaluation of antiprogesterone and PGF2αtherapy either alone or in combination for the treatment of canine pyometra. A total of twenty-three female dogs suffering from open pyometra were divided in three groups based on type of treatment viz. Group I (n = 8; PGF2α), Group II (n= 7; Mifepristone) and Group III (n = 8; PGF2α + Mifepristone). Group I dogs were administered with PGF2α @ mg/kg . bid subcutaneously for 5 days. | Efficacy of antiprogesterone and PGF2α therapy for treating canine pyometra