Bacillomycins are the cyclic lipopeptides belonging to the iturin family produced by Bacillus spp. mostly Bacillus subtilis, which are biosynthesized by multimodular proteins termed as NRPSs (non-ribosomal peptide synthetases) genes. There is tremendous research on Bacillus spp. lipopeptides or antimicrobial peptides (AMPs) showing great antagonistic potentiality of these strains, especially with bacillomycins producing genes. This review highlights the bacillomycins structure, biosynthesis, mode of action and the noteworthy antagonistic Bacillus strains with bacillomycin producing genes which have the huge potential of commercialization of these antibiotics. Moreover, an outlook is also given in a view of commercializing potential of bacillomycins against plant diseases, though there are commercial applications of bacillomycins in bio-pharmaceutical, food, textiles, pulp/paper & drug industries. | Bacillomycins – The effective molecules in plant disease management