Seven compounds were isolated and characterized from the culture broth of the marine bacteria Nocardiopsis sp. (strain G057), which was isolated from sediment collecting at Cô Tô – Quảng Ninh. Their structures were determined by spectroscopic analysis including MS and 2D NMR, as well as by comparison with reported data in the literature. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 1, 2 and 7 selectively inhibited Escherichia coli with a MIC value of 32, 64, 8 μg/mL, respectively. Compound 3 exhibited antimicrobial activity against several strains of both gram-positive and gram-negative bacteria. |
