Cây Sổ (Dillenia indica Linn) thuộc họ Sổ (Dilleniaceae) đã được sử dụng phổ biến trong đời sống hàng ngày của người dân ở Cao Bằng và các tỉnh miền núi phía Bắc như quả làm thức ăn; lá và vỏ thân chữa bệnh sỏi thận, sốt, phù thũng, đầy bụng, ho, sốt rét, cảm cúm, nhuận tràng, tiêu chảy, chống viêm nhiễm, . | TNU Journal of Science and Technology 227 08 236 - 242 STUDY ON CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF DILLENIA INDICA L. LEAVES IN CAO BANG PROVINCE Ma Thi Bich Van1 Nguyen Thanh Minh1 Dinh Thuy Van2 Tran Thi Thuy Duong3 Pham Thi Thanh Van3 Trinh Thi Hai4 Ta Thi Thu Thuy5 Nguyen Thi Ngoc Anh5 Do Tien Lam6 1CaoBang upper secondary school for the gifted 2TNU - University of Education 3TNU - University of Agriculture and Forestry 4Hanoi University of Industry 5Hanoi Open University 6Institute of Natural Products Chemistry - VAST ARTICLE INFO ABSTRACT Received 07 3 2022 Dillenia indica Linn belonging to family Dilleniaceae has been has been widely used in people s daily life in Cao Bang province and Revised 12 5 2022 Northern mountainous provinces of Vietnam as food leaves and bark Published 16 5 2022 are used to treat kidney stones fever edema bloating cough malaria colds flu laxative diarrhea anti-inflammatory etc Results of KEYWORDS quantitative analysis of some components of ethanol extract DIM from Dillenia indica leaves including moisture content total Dillenia indica ash content reducing free sugars content cellulose Anti-inflammatory content sterols content flavonoids content Antioxidant and terpenoids content . The DIM extract showed good anti- inflammatory activity inhibition of nitric oxide NO production with Liver cancer HepG2 cells IC50 value of g mL good antioxidant activity by DPPH assay Carcinoma KB cells with SC50 value of µg mL and in vitro relatively good cytotoxic activity against two human cancer cell lines liver cancer HepG2 cells and carcinoma KB cells with IC50 values of µg mL and µg mL respectively. The ethanol extract DIM from Dillenia indica leaves has the potential to be developed into medicinal products that supports human health care. NGHIÊN CỨU THÀNH PHẦN HÓA HỌC VÀ HOẠT TÍNH SINH HỌC CỦA LÁ CÂY SỔ DILLENIA INDICA L. Ở CAO BẰNG Ma Thị Bích Vân1 Nguyễn Thành Minh1 Đinh .
