Flavonoids are a diverse group of natural compounds extensively studied in various research articles. They are widely distributed in the plant kingdom and exhibit various biological activities, including antioxidant, antiinflammatory, anticancer, antiviral, and antimicrobial effects. The genus Knema Lour., which contains many species in Southeast Asia, has been traditionally used to treat various ailments. The current review aims to provide a comprehensive update on the isolation of flavonoids and other secondary metabolites from the genus Knema Lour. between 1978 and 2022. | Cite this paper Vietnam J. Chem. 2023 61 4 397-411 Minireview DOI Flavonoids and other constituents of plants from the genus Knema Myristicaceae and their pharmacological studies An updated review Abubakar Siddiq Salihu1 2 Wan Mohd Nuzul Hakimi Wan Salleh1 1 Department of Chemistry Faculty of Science and Mathematics Universiti Pendidikan Sultan Idris 35900 Tanjong Malim Perak Malaysia 2 Department of Pure and Industrial Chemistry Faculty of Natural and Applied Science Umaru Musa Yar adua University Katsina Nigeria Submitted December 7 2022 Revised March 9 2023 Accepted May 28 2023 Abstract Flavonoids are a diverse group of natural compounds extensively studied in various research articles. They are widely distributed in the plant kingdom and exhibit various biological activities including antioxidant anti- inflammatory anticancer antiviral and antimicrobial effects. The genus Knema Lour. which contains many species in Southeast Asia has been traditionally used to treat various ailments. The current review aims to provide a comprehensive update on the isolation of flavonoids and other secondary metabolites from the genus Knema Lour. between 1978 and 2022. It also discusses the pharmacological studies on these phytochemicals including their effects on nematodes bacteria cytotoxicity inflammation and acetylcholinesterase. Through these years 50 flavonoids have been reported from various species of Knema demonstrating promising pharmacological activities. The information presented in this review can provide a scientific foundation for future research on the possible therapeutic applications of Knema species. It also links the plants observed biological effects and traditional uses to their chemical characterization. The data was retrieved from various digital databases including ScienceDirect Web of Science Scopus Wiley Taylor and Francis PubMed Springer and Google Scholar. Keywords. Anacardic acids cytotoxicity flavonoids Knema Myristicaceae. .
