The methanol extracts as well as some compounds from this plant exhibited anti-inflammatory, antimicrobial activity, antioxidant, hepatoprotective and anti-cancer effect, and antiosteoporotic. On going to search for bioactive components from the Vietnamese plant, this paper reported the isolation of seven phenolic compounds including one new from the aerial parts of A. ilicifolius. The cytotoxic activity of the isolates against two cancer cell lines (HepG2 and SK-LU1) were also screened and reported herein. | Cite this paper Vietnam J. Chem. 2023 61 3 378-382 Research article DOI A previously undescribed phenolic compound from Acanthus ilicifolius L. Nguyen Thi Mai1 Le Thi Huyen2 Le Thi My Hanh2 Phan Thi Thanh Huong3 Nguyen Xuan Nhiem3 4 Bui Huu Tai3 4 Phan Van Kiem3 4 1 Faculty of Basic Sciences University of Transport and Communications Cau Giay Lang Thuong Dong Da Hanoi 10000 Viet Nam 2 University of Science Vietnam National University 334 Nguyen Trai Thanh Xuan Hanoi 10000 Viet Nam 3 Department of Structural Research Institute of Marine Biochemistry Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Cau Giay Hanoi 10000 Viet Nam 4 Faculty of Chemistry Graduate University of Science and Technology Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Cau Giay Hanoi 10000 Viet Nam Submitted February 23 2023 Revised April 17 2023 Accepted April 24 2023 Abstract The plants Acanthus ilicifolius L. Acanthaceae are used in Vietnamese folk medicine for the treatment of stomach pain hepatitis asthama and rheumatism. Phytochemical study on the methanol extract of the aerial parts of this plant led to the isolation of seven phenolic compounds 2R 3R 4R -3 4-dihydroxy-7-methoxyflavan 5-O- β-D-apiofuranosyl- 1 6 -β-D-glucopyranoside 1 quercitrin 2 isoquercitrin 3 kaempferol 3-O-α-L-arabinopyranoside 4 kaempferol 3-O-α-L-rhamnopyranoside 5 kaempferol 3-O-β-D-glucopyranoside 6 and 6-O-vanilloylarbutin 7 . Among these isolates compound 1 was previously undescribed compounds. Their chemical structures and the absolute configurations of the new compound were elucidated by 1D- 2D NMR HR-ESI-MS and ECD spectroscopic techniques. The known compounds were identified by comparison their NMR spectral data with those reported in the literature. Keywords. Acanthaceae Acanthus ilicifolius phenolic glycoside. 1. INTRODUCTION 2. MATERIALS AND METHODS Acanthus ilicifolius L. family Acanthaceae are used . Plant materials in Vietnamese folk medicine for .
