The outcomes are to be compared with typical drugs given that compounds are examined against gram-positive and gram-negative strains of bacteria and fungus. Against bacterial strains, products with nitro, methyl, and bromo substituents in the p-position of the benzene ring, as well as products with the nitro group at the m-position, showed very excellent activities against bacterial strains, while compounds with chloro substituent at p-position and m-position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum. | Received 8 April 2023 Revised 14 June 2023 Accepted 12 August 2023 DOI RESEARCH ARTICLE Design synthesis and biological evaluation studies of novel thiophene substituted thiazolidinones scaffold as promising antimicrobial agents Dinesh R. Godhani Umang P. Mehta Jignasu P. Mehta Anwar H. Saiyad Department of Chemistry DST-FIST sponsored Department Mahatma Gandhi Campus Abstract Maharaja Krishnakumarsinhji Bhavnagar Global public health is profoundly imperiled by antimicrobial resistance AMR and University Bhavnagar India has made it extremely difficult to effectively control infectious diseases which are connected to it so a new series of 5-benzylidene-2- thiophen-2-yl -3- 4H-1 2 4- Correspondence Dinesh R. Godhani Department of Chemistry triazol-4-yl thiazolidin-4-ones 5a o is synthesized. Spectral techniques have Mahatma Gandhi Campus Maharaja been utilized to characterize and confirm the structures of targeted molecules. Krishnakumarsinhji Bhavnagar University The outcomes are to be compared with typical drugs given that compounds are Bhavnagar 364002 India. Email drgodhani@ examined against gram-positive and gram-negative strains of bacteria and fun- gus. Against bacterial strains products with nitro methyl and bromo substituents Funding information in the p-position of the benzene ring as well as products with the nitro group Department of Chemistry and Maharaja at the m-position showed very excellent activities against bacterial strains while Krishnakumarsinhji Bhavnagar University compounds with chloro substituent at p-position and m-position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum. KEYWORDS 1 2 4-triazole antimicrobial activity thiazolidinone thiophene 1 INTRODUCTION many biological activities. One of the main moieties of medicinal compounds that satisfy novel drug discovery In dealing with of a range of biological activities the needs is 1 2 9 .
