In order to explore the importance of the Antheroporum genus in pharmaceutical applications, two bioactivities of A. harmandii plant extracts have been evaluated in this study. Antimicrobial and antioxidant activities of A. harmandii extracts will provide evidences for further chemical composition studies to detect new bioactive compounds from this species. | ACADEMIA JOURNAL OF BIOLOGY 2023 45 2 61 69 DOI 2615-9023 18054 ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF Antheroporum harmandii Gagnep. COLLECTED FROM QUANG TRI PROVINCE Nguyen Chi Mai1 2 Ninh Khac Ban1 2 Vu Huong Giang1 Hoang Xuan Diep3 Pham Thi Hoe1 Nguyen Tuong Van4 Tran My Linh1 2 1 Institute of Marine Biochemistry VAST Vietnam 2 Graduate University of Science and Technology VAST Vietnam 3 Department of Agriculture and Rural Development Dakrong Quang Tri Vietnam 4 VNTEST Institute for Quality Testing and Inspection Vietnam Received 31 January 2023 accepted 30 March 2023 ABSTRACT Antheroporum harmandii Gagnep. is a native plant species of Vietnam belonging to a small genus of the Fabaceae family. In this study the bioactivities of different extracts from twigs and seeds of A. harmandii plants collected from Dakrong Quang Tri province were evaluated. Antimicrobial and antioxidant activities of plant extracts had been done using an agar well diffusion method and DPPH assay. The results showed that methanol dichloromethane and ethyl acetate extracts from twigs and methanol extract from seeds exerted activities to significantly inhibit two out of nine tested microorganisms. Particularly the dichloromethane extract from the twigs sample exhibited the highest activity to Micrococcus luteus and Staphylococcus aureus strains with inhibition zones of mm and mm respectively at concentrations of 50 mg mL. The lowest MIC values 500 µg mL and 50 inhibition concentration values IC 50 against M. luteus and S. aureus were recorded for the methanol and dichloromethane extracts of twigs. Among tested extracts the ethyl acetate extract of twigs was the strongest antioxidant showing radical scavenging potential with IC50 of μg mL. Therefore A. harmandii species can be suggested as a new source for the isolation of valuable natural compounds. Keywords Antheroporum harmandii anti-microbial activity anti-bacterial activity natural compounds. .
