Pigmented Lesions See Table 32-2. Table 32-2 Pigmented Lesions of the Oral Mucosa Condition Usual Location Clinical Features Course Oral melanotic macule Any area of the mouth diffuse Discrete or Remains no localized, indefinitely; brown to black macule growth Diffuse melanin pigmentation Any area of the mouth Diffuse pale to dark-brown pigmentation; may be physiologic ("racial") Remains indefinitely or due to smoking Nevi Any area of the mouth Discrete, localized, brown Remains to indefinitely black pigmentation Malignant melanoma Any area of the mouth Can be flat and diffuse, Expands and early; painless, invades brown to black, or can metastasis leads to be raised and nodular death Addison's disease of but Any area the Blotches or Condition by steroid . | Chapter 032. Oral Manifestations of Disease Part 4 Pigmented Lesions See Table 32-2. Table 32-2 Pigmented Lesions of the Oral Mucosa Condition Usual Clinical Location Features Course Oral melanotic macule Any area Discrete or Remains of the mouth diffuse localized indefinitely no brown to black macule growth Diffuse Any area Diffuse pale to Remains melanin of the mouth dark-brown indefinitely pigmentation pigmentation may be physiologic racial or due to smoking Nevi Any area Discrete Remains of the mouth localized brown toindefinitely black pigmentation Malignant Any area Can be flat and Expands and melanoma of the mouth diffuse painless invades early brown to black or canmetastasis leads to be raised and nodular death Addison s Any area Blotches or Condition disease of the mouth spots of bluish-black tocontrolled by but mostly dark-brown adrenal steroid buccal mucosa pigmentation occurringreplacement early in the disease accompanied by diffuse pigmentation of skin other symptoms of adrenal insufficiency Peutz- Any area Dark-brown Oral Jeghers syndrome of the mouth spots on lips buccalpigmented lesions mucosa withremain indefinitely characteristic gastrointestinal distribution of pigmentpolyps may become around lips nose eyes malignant and on hands concomitant intestinal polyposis Drug Any area Brown black Gradually ingestion of the mouth or gray areas ofdisappears following neuroleptics oral pigmentation cessation of drug contraceptives
