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báo cáo hóa học:" Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis | Journal of Translational Medicine BioMed Central Research Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF implications on hepatic micrometastasis Maria Valcárcel1 Beatriz Arteta2 Arrate Jaureguibeitia1 Aritz Lopategi2 Inigo Martinez1 Lorea Mendoza1 Francisco J Muruzabal1 Clarisa Salado1 and Fernando Vidal-Vanaclocha 2 3 Address 1Pharmakine Ltd. Bizkaia Technology Park Derio Bizkaia-48160 Spain 2Basque Country University School of Medicine Dentistry Dept. Cell Biology and Histology Bizkaia-48940 Spain and 3Fernando Vidal-Vanaclocha Department of Cellular Biology and Histology School of Medicine and Dentistry University of the Basque Country Leioa Bizkaia-48940 Spain Email María Valcárcel - valcarcelcuesta@yahoo.es Beatriz Arteta - tirtxe@euskalnet.net Arrate Jaureguibeitia - ajaureguibeitia@pharmakine.com Aritz Lopategi - aritzlopategi@yahoo.es Inigo Martinez - inigo.martinez@fagmed.uit.no Lorea Mendoza - lmendoza@pharmakine.com Francisco J Muruzabal - fmuruzabal@pharmakine.com Clarisa Salado - csalado@innoprot.com Fernando Vidal-Vanaclocha - fernando.vidal@ehu.es Corresponding author Open Access Published 9 October 2008 Received 16 July 2008 Journal of Translational Medicine 2008 6 57 doi 10.1186 1479-5876-6-57 Accepted 9 October 2008 This article is available from http www.translational-medicine.com content 6 1 57 2008 Valcárcel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The recruitment of vascular stromal and endothelial cells is an early event occurring during cancer cell growth at premetastatic niches but how the microenvironment created by the initial three-dimensional 3D growth of cancer cells