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báo cáo hóa học:" ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway | Journal of Translational Medicine BioMed Central Research ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway Zhe-Yu Hu1 Jian Sun1 Xiao-Feng Zhu1 Dajun Yang2 and Yi-Xin Zeng 1 Address 1State Key Laboratory of Oncology in South China and the Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou PR China and 2Ascenta Therapeutics Incorporation Malvern Pennsylvania USA Email Zhe-Yu Hu - huzheyu24@gmail.com Jian Sun - denzel@21cn.com Xiao-Feng Zhu - zhuxfeng@mail.sysu.edu.cn Dajun Yang - dyang@Ascenta.com Yi-Xin Zeng - zengyix@mail.sysu.edu.cn Corresponding author Open Access Published 23 August 2009 Received I June 2009 Journal of Translational Medicine 2009 7 74 doi 10.1186 1479-5876-7-74 Accepted 23 August 2009 This article is available from http www.translational-medicine.cOm content 7 1 74 2009 Hu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background apogossypolone ApoG2 is a novel derivate of gossypol. We previously have reported that ApoG2 is a promising compound that kills nasopharyngeal carcinoma NPC cells by inhibiting the antiapoptotic function of Bcl-2 proteins. However some researchers demonstrate that the antiproliferative effect of gossypol on breast cancer cells is mediated by induction of cell cycle arrest. So this study was aimed to investigate the effect of ApoG2 on cell cycle proliferation in NPC cells. Results We found that ApoG2 significantly suppressed the expression of c-Myc in NPC cells and induced arrest at the DNA synthesis S phase in a large percentage of NPC cells. Immunoblot analysis showed that expression of c-Myc protein was significantly downregulated by ApoG2 and that the expression of .