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báo cáo hóa học:" Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy | Journal of Translational Medicine BioMed Central Research Regulatory activity of azabisphosphonate-capped dendrimers on human CD4 T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy Damien Portevin 1 Mary Poupot1 Olivier Rolland2 Cédric-Olivier Turrin2 Jean-Jacques Fournié1 Jean-Pierre Majoral2 Anne-Marie Caminade2 and Remy Poupot 1 Open Access Address 1INSERM U.563 Centre de Physiopathologie de Toulouse-Purpan Toulouse F-31300 Université Paul-Sabatier Toulouse F-31400 France and 2CNRS LCC Laboratoire de Chimie de Coordination 205 route de Narbonne F-31077 Toulouse France. Université de Toulouse UPS INPT LCC F-31077 Toulouse France Email Damien Portevin - dportev@nimr.mrc.ac.uk Mary Poupot - mary.poupot@inserm.fr Olivier Rolland - rolland@lcc-toulouse.fr Cédric-Olivier Turrin - turrin@lcc-toulouse.fr Jean-Jacques Fournié - fournie@toulouse.inserm.fr Jean-Pierre Majoral - majoral@lcc-toulouse.fr Anne-Marie Caminade - caminade@lcc-toulouse.fr Remy Poupot - remy.poupot@inserm.fr Corresponding authors Published 24 September 2009 Received 27 May 2009 _ _. -mno 1.O- .A I lozilz-rn ro- z 1 O-. Accepted 24 September 2009 Journal of Translational Medicine 2009 7 82 doi 10.1186 1479-5876-7-82 This article is available from http www.translational-medicine.cOm content 7 1 82 2009 Portevin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Adoptive cell therapy with allogenic NK cells constitutes a promising approach for the treatment of certain malignancies. Such strategies are currently limited by the requirement of an efficient protocol for NK cell expansion. We have developed a method using synthetic nanosized phosphonate-capped dendrimers allowing such expansion. We