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báo cáo hóa học:" Let-7 microRNAs are developmentally regulated in circulating human erythroid cells"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Let-7 microRNAs are developmentally regulated in circulating human erythroid cells | Journal of Translational Medicine BioMed Central Open Access Let-7 microRNAs are developmentally regulated in circulating human erythroid cells Seung-Jae Noh11 Samuel H Milled2 Y Terry Lee1 Sung-Ho Goh1 4 Francesco M Marincola2 David F Stroncek2 Christopher Reed3 Ena Wang2 and Jeffery L Miller 1 Address 1Molecular Medicine Branch National Institute of Diabetes Digestive and Kidney Diseases National Institutes of Health Bethesda Maryland USA 2Department of Transfusion Medicine Clinical Center National Institutes of Health Bethesda Maryland USA 3National Naval Medical Center Department of Obstetrics and Gynecology Bethesda Maryland USA and 4National Cancer Center Goyang-si Gyeonggi-do Republic of Korea Email Seung-JaeNoh-nohseung@niddk.nih.gov Samuel H Miller-shm5061@psu.edu Y TerryLee-tl100s@nih.gov Sung-Ho Goh - andrea@ncc.re.kr Francesco M Marincola - FMarincola@cc.nih.gov David F Stroncek - DStroncek@cc.nih.gov Christopher Reed - Christopher.reed@med.navy.mil Ena Wang - EWang@cc.nih.gov Jeffery L Miller - jm7f@nih.gov Corresponding author fEqual contributors Published 25 November 2009 Received 12 November 2009 Journal of Translational Medicine 2009 7 98 doi l0.ll86 l479-5876-7-98 Accepted 25 November 2009 This article is available from http www.translational-medicine.com content 7 1 98 2009 Noh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background MicroRNAs are 22nt-long small non-coding RNAs that negatively regulate protein expression through mRNA degradation or translational repression in eukaryotic cells. Based upon their importance in regulating development and terminal differentiation in model systems erythrocyte microRNA profiles were examined at birth and in adults to determine if changes in .