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báo cáo hóa học: " Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription | Journal of Neuroinflammation BioMed Central Research Open Access Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription Michiyo Tomita 1 Brita J Holman2 Christopher P Santoro3 and Thomas J Santoro1 4 Address Department of Medicine University of North Dakota School of Medicine Health Sciences 501 North Columbia Road Grand Forks ND 58201 USA 2Boston University 140 Commonwealth Avenue Chestnut Hill MA 02467 USA 3Loyola University - Chicago 6525 North Sheridan Road Chicago IL 60626 USA and 4Research Service Fargo VA Medical Center 2101 Elm Street Fargo ND 58102 USA Email Michiyo Tomita - mtomita@medicine.nodak.edu Brita J Holman - bjholman@bu.edu Christopher P Santoro - csantor@luc.edu Thomas J Santoro - tsantoro@medicine.nodak.edu Corresponding author Published 25 February 2005 Received 21 January 2005 Journal ofNeuroinflammation 2005 2 8 doi 10.1186 1742-2094-2-8 Accepted 25 February 2005 This article is available from http www.jneuroinflammation.cOm content 2 1 8 2005 Tomita et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In neuropathological processes associated with neutrophilic infiltrates such as experimental allergic encephalitis and traumatic injury of the brain the CXC chemokine macrophage inflammatory protein-2 MIP-2 is thought to play a pivotal role in the induction and perpetuation of inflammation in the central nervous system CNS . The origin of MIP-2 in inflammatory disorders of the brain has not been fully defined but astrocytes appear to be a dominant source of this chemokine. Curcumin is a spice principle in and constitutes approximately 4 percent of turmeric. Curcumin s immunomodulating .