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báo cáo hóa học: " A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices | Journal of Neuroinflammation BioMed Central Research Open Access A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices Jari Huuskonen 1 Tiina Suuronen1 Riitta Miettinen1 3 Thomas van Groen2 3 and Antero Salminen1 3 Address Department of Neuroscience and Neurology University of Kuopio PO Box 1627 FIN-70211 Kuopio Finland 2Department of Cell Biology University of Alabama at Birmingham Birmingham AL 35294-0006 USA and 3Department of Neurology University Hospital of Kuopio PO Box 1627 FIN-70211 Kuopio Finland Email Jari Huuskonen - Jari.Huuskonen@uku.fi Tiina Suuronen - Tiina.Suuronen@uku.fi Riitta Miettinen - Riitta.Miettinen@uku.fi Thomas van Groen - vangroen@uab.edu Antero Salminen - Antero.Salminen@uku.fi Corresponding author Published 15 November 2005 Received 04 November 2005 __ AA1- . A I IO I7A AAoa 1 If Accepted 15 November 2005 Journal of Neuroinflammation 2005 2 25 doi l0.ll86 1742-2094-2-25 This article is available from http www.jneuroinflammation.com content 2 1 25 2005 Huuskonen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Propagated tissue degeneration especially during aging has been shown to be enhanced through potentiation of innate immune responses. Neurodegenerative diseases and a wide variety of inflammatory conditions are linked together and several anti-inflammatory compounds considered as having therapeutic potential for example in Alzheimer s disease AD . In vitro brain slice techniques have been widely used to unravel the complexity of neuroinflammation but rarely has the power of the model itself been reported. Our aim was to gain a more detailed insight and understanding of the .