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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease | Journal of Neuroinflammation BioMed Central Research Open Access Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson s disease Rattanavijit Vijitruth Mei Liu Dong-Young Choi Xuan V Nguyen Randy L Hunter and Guoying Bing Address Department of Anatomy and Neurobiology University of Kentucky 800 Rose Street Lexington KY 40536 USA Email Rattanavijit Vijitruth - rviji2@uky.edu Mei Liu - mliu3@uky.edu Dong-Young Choi - dchoi2@uky.edu Xuan V Nguyen - nxuan2@pop.uky.edu Randy L Hunter - rhunt2@uky.edu Guoying Bing - gbing@uky.edu Corresponding author Published 27 March 2006 Received 18 January 2006 Accepted 27 March 2006 Journal of Neuroinflammation2006 3 6 doi 10.1186 1742-2094-3-6 This article is available from http www.jneuroinflammation.cOm content 3 1 6 2006Vijitruth et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson s disease PD . Among many inflammatory factors found in the PD brain cyclooxygenase COX specifically the inducible isoform COX-2 is believed to be a critical enzyme in the inflammatory response. Induction of COX-2 is also found in an experimental model of PD produced by administration of 1-methy-4-phenyl-1 2 3 6-tetrahydropyridine MPTP . Method COX-2-deficient mice or C57BL 6 mice were treated with MPTP to investigate the effects of COX-2 deficiency or by using various doses of valdecoxib a specific COX-2 inhibitor which induces inhibition of COX-2 on dopaminergic neuronal toxicity and locomotor activity impairment. Immunohistochemistry stereological cell counts immunoblotting an automated spontaneous locomotor .