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báo cáo hóa học: " Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer’s disease"

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer’s disease | Yu et al. Journal of Neuroinflammation 2011 8 136 http www.jneuroinflammation.eom content 8 1 136 JJOURNAL1 OF. NEUROINFLAMMATION SHORT REPORT Open Access Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer s disease Jin-Tai Yu1 2t Shan-Mao Mou1 3t Li-Zhu Wang4 Cai-Xia Mao1 3 and Lan Tan1 2 Abstract Background Toll-like receptor 2 TLR2 represents a reasonable functional and positional candidate gene for Alzheimer s disease AD as it is located under the linkage region of AD on chromosome 4q and functionally is involved in the microglia-mediated inflammatory response and amyloid-p clearance. The -196 to -174 del polymorphism affects the TLR2 gene and alters its promoter activity. Methods We recruited 800 unrelated Northern Han Chinese individuals comprising 400 late-onset AD LOAD patients and 400 healthy controls matched for gender and age. The -196 to -174 del polymorphism in the TLR2 gene was genotyped using the polymerase chain reaction PCR method. Results There were significant differences in genotype P 0.026 and allele P 0.009 frequencies of the -196 to -174 del polymorphism between LOAD patients and controls. The del allele was associated with an increased risk of LOAD OR 1.31 95 CI 1.07-1.60 Power 84.9 . When these data were stratified by apolipoprotein E ApoE e4 status the observed association was confined to ApoE e4 non-carriers. Logistic regression analysis suggested an association of LOAD with the polymorphism in a recessive model OR 1.64 95 CI 1.13-2.39 Bonferroni corrected P 0.03 . Conclusions Our data suggest that the -196 to -174 del del genotype of TLR2 may increase risk of LOAD in a Northern Han Chinese population. Keywords Alzheimer s disease toll-like receptor 2 polymorphism association study Background Toll-like receptor 2 TLR2 represents a reasonable functional and positional candidate gene for Alzheimer s disease AD as it is located under the linkage region of AD on chromosome 4q 1

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