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báo cáo hóa học:" Prophylaxis of heterotopic ossification – an updated review"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Prophylaxis of heterotopic ossification – an updated review | Journal of Orthopaedic Surgery and Research BioMed Central Open Access Prophylaxis of heterotopic ossification - an updated review Evan O Baird2 and Qian K Kang 1 2 Address 1Clemson University Department of Bioengineering Clemson SC USA and 2Medical University of South Carolina Department of Orthopaedic Surgery Charleston SC USA Email Evan O Baird - bairde@musc.edu Qian K Kang - kangqk@musc.edu Corresponding author Published 20 April 2009 Journal of Orthopaedic Surgery and Research 2009 4 12 doi 10.1186 1749-799X-4-12 Received 19 July 2008 Accepted 20 April 2009 This article is available from http www.josr-online.eom content 4 1 12 2009 Baird and Kang licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Heterotopic ossification HO is defined as the process by which trabecular bone forms outside of the skeletal structure occupying space in soft tissue where it does not normally exist. The current popular prophylactic treatment modalities include non-steroidal anti-inflammatory drugs NSAIDs and radiation therapy although the literature remains inconclusive as to which is superior. Additionally both treatments can lead to adverse effects to the patient. Recently there have been several studies attempting to identify new aspects of the etiology of heterotopic bone formation and introduce new prophylactic modalities with increased efficacy and fewer side effects. For this review we selectively retrieved articles from Medline published from 1958-2008 on the prophylaxis of HO with the aim of assisting readers in quickly grasping the current status of research and clinical aspects of HO prophylaxis. Background Heterotopic ossification HO is defined as