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Báo cáo hóa học: " Epidemics to eradication: the modern history of poliomyelitis"

Tham khảo tài liệu 'báo cáo hóa học: " epidemics to eradication: the modern history of poliomyelitis"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Open Access Review Epidemics to eradication the modern history of poliomyelitis Nidia H De Jesus Address Department of Molecular Genetics Microbiology Stony Brook University School of Medicine Stony Brook New York USA Email Nidia H De Jesus - nidia.dejesus@stonybrook.edu Corresponding author Published 10 July 2007 Received 27 May 2007 Virology Journal 2007 4 70 doi 10.1186 1743-422X-4-70 Accepted I0 July 2007 This article is available from http www.virologyj.cOm content 4 1 70 2007 De Jesus licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Poliomyelitis has afflicted humankind since antiquity and for nearly a century now we have known the causative agent poliovirus. This pathogen is an enterovirus that in recent history has been the source of a great deal of human suffering. Although comparatively small its genome is packed with sufficient information to make it a formidable pathogen. In the last 20 years the Global Polio Eradication Initiative has proven successful in greatly diminishing the number of cases worldwide but has encountered obstacles in its path which have made halting the transmission of wild polioviruses a practical impossibility. As we begin to realize that a change in strategy may be crucial in achieving success in this venture it is imperative that we critically evaluate what is known about the molecular biology of this pathogen and the intricacies of its interaction with its host so that in future attempts we may better equipped to more effectively combat this important human pathogen. Background The word poliomyelitis the medical term used to describe the effect of poliovirus PV on the spinal cord is derived from the Greek words for gray polio and marrow mye-lon .