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Báo cáo hóa học: " Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing"

Tham khảo tài liệu 'báo cáo hóa học: " progressive loss of cd3 expression after htlv-i infection results from chromatin remodeling affecting all the cd3 genes and persists despite early viral genes silencing"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Open Access Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing Haidar Akb1 Bassam Badran 1 Gratiela Dobirta1 Germain Manfouo-Foutsop2 Maria Moschitta1 Makram Merimi1 Arsène Burny1 Philippe Martiat 1 and Karen E Willard-Gallo2 Address laboratory of Experimental Hematology Institut Jules Bordet Université Libre de Bruxelles ULB 121 Boulevard de Waterloo 1000 Brussels Belgium and 2Molecular Immunology Unit Institut Jules Bordet Université Libre de Bruxelles ULB 127 Boulevard de Waterloo 1000 Brussels Belgium Email Haidar Akl - haidaakl@ulb.ac.be Bassam Badran - bbadran@ulb.ac.be Gratiela Dobirta - adobirta@ulb.ac.be Germain Manfouo-Foutsop - mfoutsop@hotmail.com Maria Moschitta - maria.moschitta@hotmail.com Makram Merimi - mmerimi@hotmail.com Arsène Burny-burny.a@fsagx.ac.be Philippe Martiat - pmartiat@ulb.ac.be Karen E Willard-Gallo - kwillard@ulb.ac.be Corresponding author fEqual contributors Published 6 September 2007 Received 31 July 2007 Accepted 6 September 2007 Virology journal 2007 4 85 doi 10.1186 1743-422X-4-85 This article is available from http www.virologyj.cOm content 4 1 85 2007 Akl et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background HTLV-I infected CD4 T-cells lines usually progress towards a CD3- or CD3low phenotype. In this paper we studied expression kinetics chromatin remodeling of the CD3 gene at different time-points post HTLV-I infection. Results The onset of this phenomenon coincided with a decrease of CD3ỵ followed by the subsequent progressive reduction in