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Báo cáo hóa học: " Thiol-reactive reagents inhibits intracellular trafficking of human papillomavirus type 16 pseudovirions by binding to cysteine residues of major capsid protein L1"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Thiol-reactive reagents inhibits intracellular trafficking of human papillomavirus type 16 pseudovirions by binding to cysteine residues of major capsid protein L1 | Virology Journal BioMed Central Research Open Access Thiol-reactive reagents inhibits intracellular trafficking of human papillomavirus type 16 pseudovirions by binding to cysteine residues of major capsid protein L1 Yoshiyuki Ishii1 Kazunari Kondo1 Tamae Matsumoto1 Keiko Tanaka2 Fumiko Shinkai-Ouchi3 Ken ichi Hagiwara3 and Tadahito Kanda 1 Address 1Center for Pathogen Genomics National Institute of Infectious Diseases 1-23-1 Toyama Shinjuku-ku Tokyo 162-8640 Japan 2Department of Pathology National Institute of Infectious Diseases 1-23-1 Toyama Shinjuku-ku Tokyo 162-8640 Japan and 3Department of Biochemistry and Cell Biology National Institute of Infectious Diseases 1-23-1 Toyama Shinjuku-ku Tokyo 162-8640 Japan Email Yoshiyuki Ishii - yishii@nih.go.jp Kazunari Kondo - k-kondo@nih.go.jp Tamae Matsumoto - tmmtsmt@nih.go.jp Keiko Tanaka - keiko5@nih.go.jp Fumiko Shinkai-Ouchi - fumi-ouc@nih.go.jp Ken ichi Hagiwara - hagiwark@nih.go.jp Tadahito Kanda - kanda@nih.go.jp Corresponding author Published 26 October 2007 Received 10 July 2007 Accepted 26 October 2007 Virology Journal 2007 4 110 doi 10.1186 1743-422X-4-110 This article is available from http www.virologyj.com content 4 1 1 10 2007 Ishii et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A human papillomavirus HPV virion is composed of capsid proteins L1 and L2. Several cysteine residues are located on L1 of various HPVs at markedly similar relative positions suggesting their important functions. Although the authentic virions cannot be studied with cultured cells surrogate pseudovirions consisting of capsid and reporter plasmid are available for studies dealing with infectivity. Results HPV type16-pseudovirions 16PVs were found to lose their .