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Báo cáo hóa học: " Wild type measles virus attenuation independent of type I IFN"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Wild type measles virus attenuation independent of type I IFN | Virology Journal BioMed Central Research Open Access Wild type measles virus attenuation independent of type I IFN Johan Druelle 1 Caroline I Sellin1 Diane Waku-Kouomou1 2 Branka Horvat1 and Fabian T Wild1 2 Address 1Inserm U758 Lyon F-69365 France Ecole Normale Supérieure de Lyon Lyon F-69007 France IFR128 BioSciences Lyon-Gerland Lyon-Sud Université de Lyon 1 21 Avenue Tony Garnier 69365 Lyon Cedex 07 - France and 2Centre National de Référence pour la Rougeole Lyon France Email Johan Druelle - druelle@cervi-lyon.inserm.fr Caroline I Sellin - sellin@cervi-lyon.inserm.fr Diane Waku-Kouomou - waku@cervi-lyon.inserm.fr Branka Horvat - horvat@cervi-lyon.inserm.fr Fabian T Wild - fabian.wild@btinternet.com Corresponding author Published 3 February 2008 Received 12 November 2007 Accepted 3 February 2008 Virology Journal 2008 5 22 doi l0.ll86 l 743-422X-5-22 This article is available from http www.virologyj.cOm content 5 1 22 2008 Druelle et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Measles virus attenuation has been historically performed by adaptation to cell culture. The current dogma is that attenuated virus strains induce more type I IFN and are more resistant to IFN-induced protection than wild type wt . Results The adaptation of a measles virus isolate G954-PBL by 13 passages in Vero cells induced a strong attenuation of this strain in vivo. The adapted virus G954-V13 differs from its parental strain by only 5 amino acids 4 in P V C and 1 in the M gene . While a vaccine strain Edmonston Zagreb could replicate equally well in various primate cells both G954 strains exhibited restriction to the specific cell type used initially for their propagation. Surprisingly we observed that both G954 .