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Báo cáo hóa học: " Pathogenesis and vertical transmission of a transplacental rat cytomegalovirus"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Pathogenesis and vertical transmission of a transplacental rat cytomegalovirus | Virology Journal BioMed Central Research Open Access Pathogenesis and vertical transmission of a transplacental rat cytomegalovirus Hwei-San Loh1 Mohd-Azmi Mohd-Lila 1 Sheikh-Omar Abdul-Rahman2 and Lik-Jun Kiew2 Address institute of Bioscience Universiti Putra Malaysia Serdang Selangor Malaysia and 2Department of Pathology and Microbiology Faculty of Veterinary Medicine Universiti Putra Malaysia Serdang Selangor Malaysia Email Hwei-San Loh - sandylhs@mail2world.com Mohd-Azmi Mohd-Lila - azmi@ibs.upm.edu.my Sheikh-Omar Abdul- Rahman - sheikh@vet.upm.edu.my Lik-Jun Kiew - likjunk@hotmail.com Corresponding author Published 01 June 2006 Received 18 January 2006 Accepted 01 June 2006 Virology Journal 2006 3 42 doi 10.1 186 1743-422X-3-42 This article is available from http www.virologyj.cOm content 3 1 42 2006 Loh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cytomegalovirus CMV congenital infection is the major viral cause of well-documented birth defects in human. Because CMV is species-specific the main obstacle to developing animal models for congenital infection is the difference in placental architecture which preludes virus transmission across the placenta. The rat placenta resembling histologically to that of human could therefore facilitate the study of CMV congenital infection in human. Results In this report we present clear evidences of the transplacental property of a new rat CMV RCMV namely ALL-03 which had been isolated from placenta and uterus of the house rat. Our study signifies the detection of infectious virus virus particles viral protein and DNA as well as immune response to demonstrate a natural model of acute CMV infection including the immunocompetent and immunocompromised .