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báo cáo hóa học:" Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma | Takikita et al. Journal of Translational Medicine 2011 9 126 http www.translational-medicine.eom content 9 1 126 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma 1Ỷ I-X 1Ỷ 2 1 1 3 Mikiko Takikita Ran Xie Joon-Yong Chung Hanbyoul Cho Kris Ylaya Seung-Mo Hong Christopher A Moskaluk4 and Stephen M Hewitt1 2 Abstract Background Head and neck squamous cell carcinoma HNSCC still remains a lethal malignancy benefiting from the identification of the new target for early detection and or development of new therapeutic regimens based on a better understanding of the biological mechanism for treatment. The overexpression of Her2 and Her3 receptors have been identified in various solid tumors but its prognostic relevance in HNSCC remains controversial. Methods Three hundred eighty-seven primary HNSCCs 20 matching metasis and 17 recurrent HNSCCs were arrayed into tissue microarrays. The relationships between Her2 and Her3 protein expression and clinicopathological parameters survival of HNSCC patients were analyzed with immunohistochemistry. Results Her3 is detected as either a cytoplasmic or a membranous dominant expression pattern whereas Her2 expression showed uniform membranous form. In primary tumor tissues high membranous Her2 expression level was found in 104 26.9 cases while positive membranous and cytoplasmic Her3 expression was observed in 34 8.8 and 300 77.5 samples respectively. Membranous Her2 expression was significantly associated with histological grade P 0.021 as grade 2 tumors showed the highest positive expression. Membranous Her3 overexpression was significantly prevalent in metastatic tissues compared to primary tumors P 0.003 . Survival analysis indicates that membranous Her3 expression is significantly associated with worse overall survival P 0.027 and is an independent prognostic factor in multivariate analysis hazard ratio 1.51 95 .