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báo cáo hóa học:" Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned "

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned | BioMed Central Virology Journal Research Open Access Simian immunodeficiency virus SIV envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251 increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals Jennifer L Greenier1 Koen KA Van Rompay1 David Montefiori2 Patricia Earl3 Bernard Moss3 and Marta L Marthas 1 4 Address California National Primate Research Center University of California Davis CA 95616 USA 2Duke University Medical Center Durham NC 27710 USA 3Laboratory of Viral Diseases National Institutes of Health Bethesda MD 20892 USA and 4Department of Pathology Microbiology and Immunology School of Veterinary Medicine University of California Davis CA 95616 USA Email Jennifer L Greenier - jlgreenier@yahoo.com Koen KA Van Rompay - kkvanrompay@ucdavis.edu David Montefiori - monte@acpub.duke.edu Patricia Earl - PEARL@niaid.nih.gov Bernard Moss - BMOSS@niaid.nih.gov Marta L Marthas - mlmarthas@ucdavis.edu Corresponding author Published 14 February 2005 Received 24 December 2004 Accepted 14 February 2005 Virology Journal 2005 2 11 doi l0.ll86 l 743-422X-2- II This article is available from http www.virologyj.cOm content 2 1 1 1 2005 Greenier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Oral infection of infant macaques with simian immunodeficiency virus SIV is a useful animal model to test interventions to reduce postnatal HIV transmission via breast-feeding. We previously demonstrated that immunization of infant rhesus macaques with either modified vaccinia virus Ankara MVA expressing SIV Gag Pol and Env or live-attenuated SIVmac1A11 resulted in lower viremia and longer .