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báo cáo hóa học:" PTTG: an important target gene for ovarian cancer therapy"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : PTTG: an important target gene for ovarian cancer therapy | Journal of Ovarian Research BioMed Central Open Access Review PTTG an important target gene for ovarian cancer therapy Siva Kumar Panguluri Casey Yeakel and Sham S Kakar Address Department of Physiology and Biophysics James Graham Brown Cancer Center University of Louisville Louisville KY 40202 USA Email Siva Kumar Panguluri - skpang01@gwise.louisville.edu Casey Yeakel - casey.yeakel@centre.edu Sham S Kakar - sskaka01@louisville.edu Corresponding author Published 20 October 2008 Received 16 September 2008 Journal of Ovarian Research 2008 1 6 doi l0.ll86 l757-22l5-l-6 Accepted 20 October 2008 This article is available from http www.ovarianresearch.com content l l 6 2008 Panguluri et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Pituitary tumor transforming gene PTTG also known as securin is an important gene involved in many biological functions including inhibition of sister chromatid separation DNA repair organ development and expression and secretion of angiogenic and metastatic factors. Proliferating cancer cells and most tumors express high levels of PTTG. Overexpression of PTTG in vitro induces cellular transformation and development of tumors in nude mice. The PTTG expression levels have been correlated with tumor progression invasion and metastasis. Recent studies show that down regulation of PTTG in tumor cell lines and tumors in vivo results in suppression of tumor growth suggesting its important role in tumorigenesis. In this review we focus on PTTG structure sub-cellular distribution cellular functions and role in tumor progression with suggestions on possible exploration of this gene for cancer therapy. Introduction Although .