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báo cáo hóa học:" Predictive value of ovarian stroma measurement for cardiovascular risk in polycyctic ovary syndrome: a case control study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Predictive value of ovarian stroma measurement for cardiovascular risk in polycyctic ovary syndrome: a case control study | Loverro et al. Journal of Ovarian Research 2010 3 25 http www.ovarianresearch.eom content 3 1 25 RESEARCH JOURNAL OF OVARIAN RESEARCH Open Access Predictive value of ovarian stroma measurement for cardiovascular risk in polycyctic ovary syndrome a case control study 1 2 1 1 s I 1 Giuseppe Loverro Giovanni De Pergola Edoardo Di Naro Massimo Tartagni Cristina Lavopa Anna Maria Caringella 1 Abstract Background To verify the feasibility of ovarian stromal evaluation and correlate ovarian parameteres echogenicity and volume with hyperandrogenism and both cardiovascular and metabolic risk factors in PCOS. Methods Twenty four young PCOS patients and twelve age-matched control women were enrolled. Diagnosis of PCOS was based on the Rotterdam criteria. Ultrasound ovarian study included ovarian volume stromal volume stromal area and stromal area total ovarian area ratio S A . Concerning hormones insulin LH FSH estradiol androstenedione testosterone DHEAS 17-hydroxy-progesterone and SHBG were measured during the early follicular phase days 2-5 . Cardiovascular risk factors were represented by fasting plasma levels of glucose lipids total and HDL-cholesterol plasminogen activator inhibitor 1 PAI-1 von-Willebrand factor vWF and adiponectin. Carotid intima-media thickness C-IMT was measured as a parameter of cardiovascular risk. Results A positive correlation between the S A ratio and plasma levels of testosterone p 0.05 and androstenedione p 0.05 was found. The stromal volume stromal area and S A ratio were also significantly and positively correlated with PAI-1 and vWF levels and with IMT in PCOS women P 0.05 . Conclusions This study shows that the ultrasound measurement of ovarian stroma is a predicting factor of hyperandrogenism degree prothrombotic factors and cardiovascular risk in patients with PCOS. Background Polycystic ovary syndrome PCOS is an endocrine disorder that affects 7-8 of women during reproductive age and is currently considered the most common cause of .