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báo cáo hóa học:" Retention in an antiretroviral therapy programme during an era of decreasing drug cost in Limbe, Cameroon"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Retention in an antiretroviral therapy programme during an era of decreasing drug cost in Limbe, Cameroon | Mosoko et al. Journal of the International AIDS Society 2011 14 32 http www.jiasociety.Org content 14 1 32 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Retention in an antiretroviral therapy programme during an era of decreasing drug cost in Limbe Cameroon 1.3 2 3 3 3 2 Jembia J Mosoko 1 Wilfred Akam Paul J Weidle John T Brooks Asabi J Aweh Thompson N Kinge Sherri Pals3 and Pratima L Raghunathan1 3 Abstract Background In 2002 Cameroon initiated scale up of antiretroviral therapy ART on 1 October 2004 a substantial reduction in ART cost occurred. We assessed the impact of this event and other factors on enrolment and retention in care among HIV-infected patients initiating ART from February 2002 to December 2005 at the single ART clinic serving the Southwest Region in Limbe Cameroon. Methods We retrospectively analyzed clinical and pharmacy payment records of HIV-infected patients initiating ART according to national guidelines. We compared two cohorts of patients enrolled before and after 1 October 2004 to determine if price reduction was associated with enhanced enrolment. We assessed factors associated with retention and survival by Cox proportional hazards models. Retention in care implied patients who had contact with the healthcare system as of 31 December 2005 including those who were transferred to continue care in other ART centres although these patients may have interrupted therapy at some time. A patient who was not retained in care may have dropped out lost to follow up or died. Results Mean enrolment rates for 2920 patients who initiated ART before and after the price reduction were 46.5 and 95.5 persons month respectively p 0.001 . The probabilities of remaining alive and in care were 0.66 95 CI 0.64-0.68 at six months 0.58 95 CI 0.56-0.60 at one year 0.47 95 CI 0.45-0.49 at two years and 0.35 95 CI 0.32-0.38 at three years they were not significantly different between the two cohorts of patients enrolled before and after the price .