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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector | Harris et al. Nanoscale Research Letters 2011 6 445 http www.nanoscalereslett.eom content 6 1 445 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Beyond platinum synthesis characterization and in vitro toxicity of Cu II -releasing polymer nanoparticles for potential use as a drug delivery vector Alesha N Harris Barbara R Hinojosa Montaleé D Chavious and Robby A Petros Abstract The field of drug delivery focuses primarily on delivering small organic molecules or DNA RNA as therapeutics and has largely ignored the potential for delivering catalytically active transition metal ions and complexes. The delivery of a variety of transition metals has potential for inducing apoptosis in targeted cells. The chief aims of this work were the development of a suitable delivery vector for a prototypical transition metal Cu2 and demonstration of the ability to impact cancer cell viability via exposure to such a Cu-loaded vector. Carboxylate-functionalized nanoparticles were synthesized by free radical polymerization and were subsequently loaded with Cu2 via binding to particle-bound carboxylate functional groups. Cu loading and release were characterized via ICP MS EDX XPS and elemental analysis. Results demonstrated that Cu could be loaded in high weight percent up to 16 wt. and that Cu was released from the particles in a pH-dependent manner. Metal release was a function of both pH and the presence of competing ligands. The toxicity of the particles was measured in HeLa cells where reductions in cell viability greater than 95 were observed at high Cu loading. The combined pH sensitivity and significant toxicity make this copper delivery vector an excellent candidate for the targeted killing of disease cells when combined with an effective cellular targeting strategy. Keywords copper polymer nanoparticles copper ion release drug delivery oxidative stress HeLa cells Introduction The field of drug delivery focuses primarily on delivering small organic