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Báo cáo hóa học: " Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers | Chen et al. Nanoscale Research Letters 2011 6 67 http www.nanoscalereslett.eom content 6 1 67 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Europium-doped amorphous calcium phosphate porous nanospheres preparation and application as luminescent drug carriers Feng Chen1 Ying-Jie Zhu1 Kui-Hua Zhang2 Jin Wu Ke-Wei Wang1 Qi-Li Tang1 Xiu-Mei Mo2 Abstract Calcium phosphate is the most important inorganic constituent of biological tissues and synthetic calcium phosphate has been widely used as biomaterials. In this study a facile method has been developed for the fabrication of amorphous calcium phosphate ACP polylactide-block-monomethoxy polyethyleneglycol hybrid nanoparticles and ACP porous nanospheres. Europium-doping is performed to enable photoluminescence PL function of ACP porous nanospheres. A high specific surface area of the europium-doped ACP Eu3 ACP porous nanospheres is achieved 126.7 m2 g . PL properties of Eu3 ACP porous nanospheres are investigated and the most intense peak at 612 nm is observed at 5 mol Eu3 doping. In vitro cytotoxicity experiments indicate that the as-prepared Eu3 ACP porous nanospheres are biocompatible. In vitro drug release experiments indicate that the ibuprofen-loaded Eu3 ACP porous nanospheres show a slow and sustained drug release in simulated body fluid. We have found that the cumulative amount of released drug has a linear relationship with the natural logarithm of release time n t . The Eu3 ACP porous nanospheres are bioactive and can transform to hydroxyapatite during drug release. The PL properties of drug-loaded nanocarriers before and after drug release are also investigated. Introduction The development of multifunctional nanosystems for maximum therapeutic benefit including early diagnoses of the diseases and delivery of suitable therapeutic drugs holds a promise for the future of clinical treatment to enhance therapeutic efficacy 1 2 . Therefore it is highly desirable to develop novel .