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Báo cáo hóa học: " Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation | Nanoscale Res Lett 2009 4 1395-1402 DOI 10.1007 s11671-009-9411-x NANO EXPRESS Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation Dadong Guo Chunhui Wu Jingyuan Li Airong Guo Qingning Li Hui Jiang Baoan Chen Xuemei Wang Received 27 June 2009 Accepted 7 August 2009 Published online 23 August 2009 to the authors 2009 Abstract The effect of functionalized nickel Ni nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells SMMC-7721 has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile the influence of Ni nanoparticles and or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing RT-CES study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane and remarkably enhance the accumulation of quercetin in SMMC-7721 cells suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells. Keywords Nickel nanoparticles Real-time cell electronic sensing RT-CES study MTT assay Electrochemical analysis Hepatocellular carcinoma cell line Introduction With the development of nanotechnology nanomaterials are now widely produced and applied in biomedical and biologic engineering 1-4 . Due to their unique D. Guo C. Wu J. Li A. Guo Q. Li H. Jiang X. Wang El State Key Lab of Bioelectronics Chien-Shiung Wu Lab Southeast University 210096 Nanjing China e-mail xuewang@seu.edu.cn B. Chen Zhongda Hospital School of Clinical Medical Southeast University 210096 Nanjing China characteristics nanomaterials and nanotechnologies are changing many basic scientific concepts in a great variety of fields and are receiving intensively increasing interest in the relative research and industrial applications. It is well known