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Báo cáo hóa học: " Alternating Magnetic Field Controlled, Multifunctional NanoReservoirs: Intracellular Uptake and Improved Biocompatibility"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Alternating Magnetic Field Controlled, Multifunctional NanoReservoirs: Intracellular Uptake and Improved Biocompatibility | Nanoscale Res Lett 2010 5 195-204 DOI 10.1007 S11671-009-9465-9 NANO EXPRESS Alternating Magnetic Field Controlled Multifunctional Nano- Reservoirs Intracellular Uptake and Improved Biocompatibility Santaneel Ghosh Somesree GhoshMitra Tong Cai David R. Diercks Nathaniel C. Mills DiAnna L. Hynds Received 7 September 2009 Accepted 5 October 2009 Published online 25 October 2009 to the authors 2009 Abstract Biocompatible magnetic nanoparticles hold great therapeutic potential but conventional particles can be toxic. Here we report the synthesis and alternating magnetic field dependent actuation of a remotely controllable multifunctional nano-scale system and its marked biocompatibility with mammalian cells. Monodisperse magnetic nanospheres based on thermo-sensitive polymer network poly ethylene glycol ethyl ether methacrylate-co-poly ethylene glycol methyl ether methacrylate were synthesized using free radical polymerization. Synthesized nanospheres have oscillating magnetic field induced thermo-reversible behavior exhibiting desirable characteristics comparable to the widely used poly-N-iso-propylacrylamide-based systems in shrinkage plus a broader volumetric transition range. Remote heating and model drug release were characterized for different field strengths. Nanospheres containing nanoparticles up to an iron concentration of 6 mM were readily taken up by neuron-like PC12 pheochromocytoma cells and had S. Ghosh H Department of Physics and Engineering Physics Southeast Missouri State University MS 6600 One University Plaza Cape Girardeau MO 63701 USA e-mail sghosh@semo.edu S. GhoshMitra N. C. Mills D. L. Hynds Department of Biology Texas Woman s University PO Box 425799 Denton TX 76204 USA T. Cai Department of Physics University of North Texas Denton TX 76203 USA D. R. Diercks Center of Advancement of Research and Technology University of North Texas Denton TX 76207 USA reduced toxicity compared to other surface modified magnetic nanocarriers. Furthermore .