The third part of the book is dedicated to analysis of role of DNA methylation in cancer. According to the American Cancer Association, nearly 13% of all deaths worldwide are cancer related. Aberrant DNA methylation patterns is likely to play a causative role in cancer initiation and development. The first chapter is dedicated to investigation of DNA methylation role in the development of hepatocellular carcinoma associated with tyrosinemia. The second chapter discusses a biological relationship between DNA methylation and histone deacetylation and their role in modulating gene repression programming. This epigenetic cross-talk may be involved in gene transcription and aberrant gene silencing in tumors. The third chapter introduces the.
