To put the odds ratios of these genetic markers in context, let’s consider the effect size of the above mentioned environmental risk factors that physicians currently use to assess patients’ likelihood of myocardial infarction. The effect size of the genetic markers 9p21 and MTHFD1L equals or surpasses the effect size of most of the currently recognized medical risk factors -- an insight which many physicians may find illuminating. Furthermore, the Navigenics risk score combines the effect of multiple independent genetic risk factors which leads to even more discrimination of risk from non-risk. In the case of myocardial infarction, if an.
