A chilly, but still very attractive, Asilomar hosted the seventh edition of the Critical Assessment of Protein Structure Prediction Experiment (CASP) [1]. A few months ago, 96 protein sequences of unknown, but soon to be determined structure, were distributed to more than 250 groups, whose task was to predict their structure and a number of other fea-tures, such as their domain boundaries, the presence of disordered regions, contacts between specific amino acids and their molecular function.