Nghiên cứu nhằm so sánh đáp ứng miễn dịch ở heo đối với 2 loại vắc xin Lở mồm long móng >3PD50 và >6PD50, dựa trên hiệu giá kháng thể trung hoà, để làm rõ sự khác biệt về hiệu quả bảo hộ của 2 loại vắc xin đối với các chủng virus Lở mồm long móng phân lập tại Việt Nam, phục vụ cho việc sử dụng vắc xin trong phòng bệnh Lở mồm long móng. | TNU Journal of Science and Technology 228 09 87 - 94 NEUTRALIZING IMMUNE RESPONSE IN WEANING PIGS AFTER VACCINATION WITH FOOD AND MOUTH DISEASE VACCINE Nguyen Ngoc Hai1 Vo Thi Kieu Oanh2 1Nonglam University in Ho Chi Minh city 2Department of animal health in Long An province ARTICLE INFO ABSTRACT Received 07 3 2023 PD50 of Foot-and-mouth disease FMD vaccine is a dose-determining index of vaccine antigen that protects 50 of vaccinated animals against a challenge with Revised 16 5 2023 virulent FMD virus. FMD vaccines classified into standard potency FMD vaccine Published 16 5 2023 gt 3PD50 and higher potency vaccine gt 6PD50 . The FMD gt 6PD50 vaccine in addition to its ability to induce a faster stronger and longer lasting immune response than the FMD gt 3PD50 vaccine can also enhance the protective effect KEYWORDS against FMDV strains of different topotypes. The study aimed to compare the FMD virus immune response in pigs to 2 types of Foot-and-mouth disease vaccines gt 3PD50 and gt 6PD50 based on neutralizing antibody titers to clarify the difference in the Vaccine protective efficacy of the two vaccines to the foot-and-mouth disease virus strains gt 6PD50 isolated in Vietnam serving the use of vaccines in the prevention of Foot-and- gt 3PD50 mouth disease. The results showed that there is a difference in immunogenicity between the two FMD vaccines gt 6PD50 and gt 3PD50. Pigs vaccinated with FMD Neutralizing immune response gt 6PD50 had a positive rate and neutralizing antibody titer against FMD virus strains belonging to the topotype O ME-SA PanAsia O SEA Mya 98 and O ME-SA Ind 2001e isolates in Vietnam were statistically significantly higher than pigs vaccinated with FMD 3PD50 P6PD50 can induce high neutralizing immunity overcoming the differences in the topology of FMD virus field and vaccine strains. The result of the study could be used for vaccination to control FMD. ĐÁP ỨNG MIỄN DỊCH TRUNG HOÀ Ở HEO CAI SỮA SAU TIÊM VẮC XIN LỞ MỒM LONG MÓNG Nguyễn Ngọc .
