From CHCl3-soluble extract of the leaves of Taxus wallichiana (Taxaceae), collected in Lam Dong Province, five compounds were isolated and identified as sciadopitysin, ginkgetin, (S)-(+)-rhododenol, (+)-erythro-N-benzoyl3-phenylisoserine methyl ester, and (−)-α-conidendrin (5). Their chemical structures were determined by 1D and 2D NMR spectra and comparison with published data. Except for (−)-α-conidendrin, these remaining compounds were first reported of Taxus wallichiana. Among these compounds, ginkgetin and (−)-αconidendrin showed significant α-glucosidase inhibitory activity with the IC50 values of , and μM, respectively. | Received 18 February 2023 Revised 30 March 2023 Accepted 24 July 2023 DOI RESEARCH ARTICLE Chemical constituents of the leaves of Taxus wallichiana Taxaceae Thinh Duc Le1 2 Da Vy Thi Le1 2 Tu Hoai Tran1 2 Phu Hoang Dang1 2 Tho Huu Le1 2 Mai Thanh Thi Nguyen1 2 Nhan Trung Nguyen1 2 1 Faculty of Chemistry University of Science Ho Chi Minh City Vietnam Abstract 2 Management Agency Vietnam National From CHCl3 -soluble extract of the leaves of Taxus wallichiana Taxaceae col- University Ho Chi Minh City Ho Chi Minh City lected in Lam Dong Province five compounds were isolated and identified as Vietnam sciadopitysin 1 ginkgetin 2 S - -rhododenol 3 -erythro-N-benzoyl- 3-phenylisoserine methyl ester 4 and -α-conidendrin 5 . Their chemical Correspondence Nhan Trung Nguyen Faculty of Chemistry structures were determined by 1D and 2D NMR spectra and comparison with pub- VNUHCM-University of Science 227 Nguyen Van lished data. Except for -α-conidendrin these remaining compounds were first Cu Street Ward 4 District 5 Ho Chi Minh City reported of Taxus wallichiana. Among these compounds ginkgetin 2 and -α- 72711 Vietnam. Email ntnhan@ conidendrin 5 showed significant α-glucosidase inhibitory activity with the IC50 values of and μM respectively. Funding information Vietnam National University Ho Chi Minh City KEYWORDS VNU-HCM Grant Award Number α-glucosidase inhibitory activity Taxaceae Taxus wallichiana 562-2022-18-04 1 INTRODUCTION showed strong α-glucosidase inhibitory activity with the IC50 value of μg mL. Hence an additional fractionation Taxus wallichiana Zucc. commonly known as the Wallich s study was undertaken to examine its chemical constituents yew is an evergreen coniferous tree of medium size reach- resulting in the isolation of five compounds. This work ing heights between 10 to 20 m. It is native to several coun- describes isolating and elucidating the chemical structures tries in Asia including Afghanistan India .
