Phytochemical study of Knema pachycarpa leaves led to the isolation of ten compounds. Their chemical structures were determined as (7''R, 8''R)-hydnocarpin D, (7''R, 8''R)-hydnocarpin, sinaicitin, (-)-globulol, β-caryolanol, phytol, biochanin A, chrysoeriol, tanoside II and astragalin using NMR and MS spectral data. Among the isolates, (7''R, 8''R)-hydnocarpin showed good cytotoxic activity against KB, HepG-2, Lu and MCF-7 cancer cell lines with IC50 values from ± ug/mL to ± ug/mL. |
