In this paper we focus on the preparation and the biofunctionalization of GNSs. The coverage of the GNSs on the surfaces of the silica NPs was evaluated using UV-VIS/NIR spectroscopy. The surphase plasmon resonance (SPR) wavelengths of these GNSs were tunable from visible to near infrared. | Biofunctionalization of gold nanoshells monitored by surphase plasmon resonance