Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats | J. Vet. Sci. 2009 10 2 141-146 DOI JOURNAL OF Veterinary Science NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats 1 t 1 t 1 1 1 1 Sung-Hoon Park Noton Kumar Dutta Min-Won Baek Dong-Jae Kim Yi-Rang Na Seung-Hyeok Seok Byoung-Hee Lee1 Ji-Eun Cho2 Geon-Sik Cho2 Jae-Hak Park1 laboratory Animal Medicine and KRF Priority Zoonotic Disease Research Institute College of Veterinary Medicine Seoul National University Seoul 151-742 Korea 2Biotech Mokpo 530-370 Korea The effect of NaCl plus 3 chitosan on the systolic blood pressure of spontaneously hypertensive rats SHR were evaluated and compared with NaCl plus KCl NaCl KCl and chitosan or NaCl treatment alone. In SHR administration of NaCl plus chitosan 44 mM Na day for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted though not statistically significant in decreased urinary Na excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels however remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model further research is needed before any recommendations can be made. Keywords chitosan hypertension KCl NaCl spontaneously hypertensive rat Introduction Hypertension is one of the most common cardiovascular diseases and has become a worldwide problem of epidemic proportions affecting 15 20 of all adults 10 11 22 26 . It is the most serious common chronic health problem because it is a significant risk factor for the development of arteriosclerosis stroke myocardial infarction and end-stage renal disease 25
