Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: β Scar wars: is TGFβ the phantom menace in scleroderma? | Available online http content 8 4 213 Review Scar wars is TGFp the phantom menace in scleroderma Andrew Leask Division of Oral Biology and Department of Physiology and Pharmacology CIHR Group in Skeletal Development and Remodeling Division of Oral Biology Schulich School of Medicine and Dentistry University of Western Ontario Dental Sciences Building London ON N6A 5C1 Canada Corresponding author Andrew Leask Published 9 June 2006 This article is online at http content 8 4 213 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 213 doi ar1976 Abstract The autoimmune disease scleroderma systemic sclerosis SSc is characterized by extensive tissue fibrosis causing significant morbidity. There is no therapy for the fibrosis observed in SSc indeed the underlying cause of the scarring observed in this disease is unknown. Transforming growth factor-p TGFP has long been hypothesized to be a major contributor to pathological fibrotic diseases including SSc. Recently the signaling pathways through which TGFp activates a fibrotic program have been elucidated and as a consequence several possible points for anti-fibrotic drug intervention in SSc have emerged. Introduction During normal connective tissue repair fibroblasts proliferate and migrate into the wound where they synthesize adhere to and contract extracellular matrix ECM proteins resulting in wound closure. It has been proposed that a failure to down-regulate the normal tissue repair program causes the pathological scarring characterizing fibrotic diseases 1 2 . Fibrotic disease can affect individual organs such as the kidney liver pancreas or lung or be systemic affecting all organs 1-5 . In its most severe forms fibrosis results in organ failure and death. The systemic autoimmune disease scleroderma systemic sclerosis SSc possesses a significant fibrotic component indeed pulmonary fibrosis is the cause of the high mortality .
