Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse. | BioMed Central Respiratory Research Research Open Access PPARa downregulates airway inflammation induced by lipopolysaccharide in the mouse Carine Delayre-Orthez1 Julien Becker1 Isabelle Guenon2 Vincent Lagente2 Johan Auwerx3 Nelly Frossard1 and Franẹoise Pons 1 Address 1EA 3771 Inflammation et environnement dans l asthme Faculté de Pharmacie Université Louis Pasteur-Strasbourg I Illkirch France 2INSERM U620 Faculté des Sciences Pharmaceutiques Université de Rennes 1 Rennes France and 3Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS Inserm ULP Illkirch France Email Carine Delayre-Orthez - orthez@ Julien Becker - becker@ Isabelle Guenon - Vincent Lagente - Johan Auwerx - auwerx@ Nelly Frossard - frossard@ Fran oise Pons - pons@ Corresponding author Published 09 August 2005 Received 26 January 2005 Respiratory Research 2005 6 91 doi 1465-9921 -6-91 Accepted 09 August 2005 This article is available from http content 6 1 91 2005 Delayre-Orthez et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inflammation is a hallmark of acute lung injury and chronic airway diseases. In chronic airway diseases it is associated with profound tissue remodeling. Peroxisome proliferator-activated receptor-a PPARa is a ligand-activated transcription factor that belongs to the nuclear receptor family. Agonists for PPARa have been recently shown to reduce lipopolysaccharide LPS - and cytokine-induced secretion of matrix metalloproteinase-9 MMP-9 in human monocytes and rat mesangial cells suggesting that PPARa may play
