One new sesquiterpene, (4S,7R,10S)-2-oxo-4,10,11-trihydroxyguaia-1(5)-ene, and five lignans, kadsuralignan J, isovaleroylbinankadsurin A, schizandrin O, futokakadsurin C and arisantetralone were isolated from the roots of Kadsura induta. Their chemical structures were revealed by MS, 1D and 2D NMR spectra in comparison with the reported data. The absolute configuration of compound 1 was determined by calculation of its theoretical ECD spectra and compared with the experimental results. | Cite this paper Vietnam J. Chem. 2023 61 5 663-671 Research Article DOI A new sesquiterpene and lignans from the roots of Kadsura induta Truong Thi Thu Hien1 Do Thi Trang2 Tran Thi Phuong Thao3 Ho Ba Ngoc Minh1 Nguyen Ba Hung1 Hoang Dac Thang1 Le Huyen Tram4 Bui Huu Tai2 Tran Thi Thu Ha5 Phan Van Kiem2 1 Vietnam Military Medical University 106 Phung Hung Phuc La Ha Dong Hanoi 10000 Viet Nam 2 Institute of Marine Biochemistry Vietnam Academy of Science and Technology VAST 18 Hoang Quoc Viet Cau Giay Hanoi 10000 Viet Nam 3 Institute of Chemistry VAST 18 Hoang Quoc Viet Cau Giay Hanoi 10000 Viet Nam 4 Hanoi University of Science and Technology 1 Dai Co Viet Hai Ba Trung Hanoi 10000 Viet Nam 5 Institute of Forestry and Sustainable Development Quyet Thang Commune Thai Nguyen University of Agriculture and Forestry Thai Nguyen City 24000 Viet Nam Submitted April 13 2023 Revised June 16 2023 Accepted July 14 2023 Abstract One new sesquiterpene 4S 7R 10S -2-oxo-4 10 11-trihydroxyguaia-1 5 -ene 1 and five lignans kadsuralignan J 2 isovaleroylbinankadsurin A 3 schizandrin O 4 futokakadsurin C 5 and arisantetralone 6 were isolated from the roots of Kadsura induta. Their chemical structures were revealed by MS 1D and 2D NMR spectra in comparison with the reported data. The absolute configuration of compound 1 was determined by calculation of its theoretical ECD spectra and compared with the experimental results. Keywords. Schisandraceae Kadsura induta sesquiterpene 4S 7R 10S -2-oxo-4 10 11-trihydroxyguaia-1 5 -ene. 1. INTRODUCTION . Experimental procedures K. induta is a climbing plant that usually grows in All related experimental procedures were described forests and found in the northern Vietnam such as in details in supporting information. Lao Cai Ha Giang provinces. The plants belonging to Kadsura have been used to treat enteritis duodenal . Extraction and isolation ulcer stomach pain or stimulate digestion. 1 The main chemical components of .
