Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis. | Available online http content 10 6 R134 Research article Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis Hui Geng1 2 Stefan Carlsen1 Kutty Selva Nandakumar1 Rikard Holmdahl1 Anders Aspberg1 3 Ảke Oldberg1 and Ragnar Mattsson1 Department of Experimental Medical Sciences BMC Lund University Solvegatan 19 SE-22184 Lund Sweden 2Current address Department of Biochemistry and Molecular Biology College of Life Science Huazhong Normal University No. 100 Luoyuroad Wuhan 430079 PR China department of Biology University of Copenhagen Biocenter Ole Maaloes Vej 5 DK-2200 Copenhagen Denmark Corresponding author Hui Geng Received 19 Jun 2008 Revisions requested 1 Aug 2008 Revisions received 22 Oct 2008 Accepted 14 Nov 2008 Published 14 Nov 2008 Arthritis Research Therapy 2008 10 R134 doi 86 ar2551 This article is online at http content 10 6 R134 2008 Geng et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Cartilage oligomeric matrix protein COMP is a homopentameric protein in cartilage. The development of arthritis like collagen-induced arthritis CIA involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. Methods COMP-deficient mice in the 129 Sv background were backcrossed for 10 generations against mice which are susceptible to chronic CIA. COMP-deficient and wild-type mice were tested for onset incidence and severity of arthritis in both the collagen and collagen antibody-induced arthritis models. Serum anti-collagen II and anti-COMP antibodies as well as serum COMP levels in arthritic and .
