Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Surfactant gene polymorphisms and interstitial lung diseases. | Available online http content 3 1 14 Review Surfactant gene polymorphisms and interstitial lung diseases Panagiotis Pantelidis Srihari Veeraraghavan and Roland M du Bois Interstitial Lung Disease Unit Department of Occupational and Environmental Medicine Imperial College of Science Technology and Medicine National Heart and Lung Institute Royal Brompton Hospital London UK Correspondence Dr Srihari Veeraraghavan Interstitial Lung Disease Unit Department of Occupational and Environmental Medicine Royal Brompton Hospital 1B Manresa Road London SW3 6LR UK. Tel 44 020 7351 8327 fax 44 020 7351 8336 e-mail Received 20 July 2001 Revisions requested 8 August 2001 Revisions received 17 August 2001 Accepted 31 August 2001 Published 29 November 2001 Respir Res 2002 3 14 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Pulmonary surfactant is a complex mixture of phospholipids and proteins which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been reported in several interstitial lung diseases ILDs . Furthermore a mutation in the surfactant protein C gene that results in complete absence of the protein has been shown to be associated with familial ILD. The role of surfactant in lung disease is therefore drawing increasing attention following the elucidation of the genetic basis underlying its surface expression and the proof of surfactant abnormalities in ILD. Keywords genetics interstitial lung disease polymorphism surfactant Introduction The role of surfactant in interstitial lung disease ILD has drawn increasing attention in recent years particularly with the publication of the genetic determinants of surfactant expression. This review will focus on surfactant abnormalities in ILD with emphasis on surfactant protein SP gene polymorphisms. Pulmonary surfactant is a mixture of phospholipids and surfactant-specific proteins
