Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Serum levels of soluble Fas, soluble tumor necrosis factor-receptor II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4. | Zekri et al. Comparative Hepatology 2010 9 1 http content 9 1 1 COMPARATIVE HEPATOLOGY RESEARCH Open Access Serum levels of soluble Fas soluble tumor necrosis factor-receptor II interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4 Abdel-Rahman N Zekri1 Hanaa M Alam El-Din1 Abeer A Bahnassy2 Naglaa A Zayed3 Waleed S Mohamed1 Suzan H El-Masry4 Sayed K Gouda4 Gamal Esmat3 Abstract Background Liver disease progression from chronic hepatitis C virus HCV infection to hepatocellular carcinoma HCC is associated with an imbalance between T-helper 1 and T-helper 2 cytokines. Evaluation of cytokines as possible candidate biomarkers for prediction of HCC was performed using soluble Fas sFas soluble tumor necrosis factor receptor-II sTNFR-II interleukin-2 receptor IL-2R and interleukin-8 IL-8 . Results The following patients were recruited 79 with HCV infection 30 with HCC 32 with chronic liver disease associated with elevated liver enzyme levels with or without cirrhosis in addition to 17 with chronic HCV with persistent normal alanine aminotransferase levels PNALT . Nine normal persons negative either for HCV or for hepatitis B virus were included as a control group. All persons were tested for sFas sTNFR-II IL-2R and IL-8 in their serum by quantitative ELISA. HCC patients had higher levels of liver enzymes but lower log-HCV titer when compared to the other groups. HCC patients had also significantly higher levels of sFas sTNFR-II and IL-2R and significantly lower levels of IL-8 when compared to the other groups. Exclusion of HCC among patients having PNALT could be predicted with 90 sensitivity and specificity when sTNFR-II is 389 pg ml or IL-8 is 290 pg ml. Conclusions Serum TNFR-II IL-2Ra and IL-8 may be used as combined markers in HCV-infected cases for patients at high risk of developing HCC further studies however are mandatory to check these .
